||FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis.
Atsuta, YujiTakahashi, Yoshiko
2337 , 2015-07-01 , Company of Biologists Ltd.
胚成長と連動する管組織形成メカニズムの解明 －臓器不全治療や再生医療に期待－. 京都大学プレスリリース. 2015-07-03.
When a tubular structure forms during early embryogenesis, tubular elongation and lumen formation (epithelialization) proceed simultaneously in a spatiotemporally coordinated manner. We here demonstrate, using the Wolffian duct (WD) of early chicken embryos, that this coordination is regulated by the expression of FGF8, which shifts posteriorly during body axis elongation. FGF8 acts as a chemoattractant on the leader cells of the elongating WD and prevents them from epithelialization, whereas static ('rear') cells that receive progressively less FGF8 undergo epithelialization to form a lumen. Thus, FGF8 acts as a binary switch that distinguishes tubular elongation from lumen formation. The posteriorly shifting FGF8 is also known to regulate somite segmentation, suggesting that multiple types of tissue morphogenesis are coordinately regulated by macroscopic changes in body growth.