Journal Article IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer.

Abiko, K  ,  Matsumura, N  ,  Hamanishi, J  ,  Horikawa, N  ,  Murakami, R  ,  Yamaguchi, K  ,  Yoshioka, Y  ,  Baba, T  ,  Konishi, I  ,  Mandai, M

112 ( 9 )  , pp.1501 - 1509 , 2015-03-31 , Nature Publishing Group
PD-L1 (programmed cell death 1 ligand 1) on tumour cells suppresses host immunity through binding to its receptor PD-1 on lymphocytes, and promotes peritoneal dissemination in mouse models of ovarian cancer. However, how PD-L1 expression is regulated in ovarian cancer microenvironment remains unclear.

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