||Clinicopathological features of mucoepidermoid carcinoma．
Yamazaki, Keisuke山崎, 恵介
学位の種類: 博士（医学）. 報告番号: 乙第2208号. 学位記番号: 新大院博（医）乙第1787号. 学位授与年月日: 平成29年3月23日
The Journal of Laryngology & Otology (2014), 128, 91–95.
Objective: We aimed to examine the clinical usefulness of a new World Health Organization classification scheme for salivary gland mucoepidermoid carcinoma, and to identify the factors most strongly associated with prognosis and outcome. Methods: The clinicopathological features of 45 patients who received treatment for mucoepidermoid carcinoma between 1986 and 2010 were retrospectively investigated.Results: The overall disease-specific 5-year survival rate was 81.8 per cent. The rate for patients with low-grade tumours (92.5 per cent) was significantly higher than that for patients with intermediate or high-grade tumours (52.2 per cent). Univariate analysis revealed that five factors were significantly associated with five-year survival: age, tumour stage classification, lymph node status, histological grade and treatment method. Four factors were significant in multivariate analysis: age, sex, tumour stage classification and lymph node status. Conclusion: The new World Health Organization classification was useful in predicting disease progression in patients with mucoepidermoid carcinoma. Patients with high-grade tumours or other prognostic factors positively associated with disease progression should be carefully evaluated and monitored.