||Donor killer immunoglobulin-like receptor haplotype B/x induces severe acute graft-versus-host disease in the presence of HLA mismatch in T-cell replete hematopoietic cell transplantation.
Hosokai, Ryosuke細貝, 亮介
学位の種類: 博士（医学）. 報告番号: 甲第4261号. 学位記番号: 新大院博（医）甲第739号. 学位授与年月日: 平成29年3月23日
Biology of Blood and Marrow Transplantation 23(4)606-611,2017
Natural killer cells have been identified as a mediator of alloimmune reactions in allogeneic hematopoietic stem cell transplantation (HSCT). Killer immunoglobulin-like receptors (KIRs) are an important determinant of natural killer cell function. The relationship between KIR genotypes/haplotypes and clinical outcomes of allogeneic HSCT is complex and inconsistent among several reports. We assessed the clinical impact of KIR haplotype on T cell–replete allogeneic HSCTs performed in a single Japanese center for hematological malignancies (n = 106). A comparison of 2 groups, donor haplotypes A/A and B/x, revealed no significant differences in overall survival, relapse, and nonrelapse mortality. However, grade III to IV acute graft-versus-host disease (GVHD) occurred significantly more frequently in the KIR haplotype B/x group (A/A versus B/x: 4.9% versus 20.0%; P = .02). This was even more evident when HLA mismatch was present. The highest incidences of grade II to IV and grade III to IV acute GVHD were observed in patients who received allografts from HLA-mismatched donors with KIR haplotype B/x. These data highlight the importance of KIR genotyping in donor matching, especially when HLA mismatch allogeneic grafting is planned.