||Body Weight Reduction Results in Favorable Changes in Blood Pressure, Serum Lipids, and Blood Sugar in Middle-Aged Japanese Persons : A 5-Year Interval Observational Study of 26,824 Cases
日本人中年において体重低下は血圧、血清脂質、血糖値に好ましい変化をもたらす : 26,824名を対象とする5年間隔で実施した観察研究
Mandai, Nozomu萬代, 望
学位の種類: 博士（学術）. 報告番号: 甲第4076号. 学位記番号: 新大院博（学）甲第36号. 学位授与年月日: 平成27年9月24日
Global Journal of Health Science. 2015, 7(5), 159-170.
Objective: We investigated the relationships between body weight (BWt) and metabolic syndrome (MS) risk factors to elucidate the effect of BWt (ΔBWt) change and body mass index (BMI) on these factors in the Japanese population. Methods: Data were collected on MS-related parameters measured during two annual examinations of 16,640 men (mean age: 41.7±11.6 years) and 10,184 women (mean age: 45.0±12.2 years) without prior treatment of hypertension, diabetes mellitus, or dyslipidemia in 2006 and 2011 in Fukuoka, Japan. The subjects were divided into three groups according to BMI in 2006 (low, middle and high BMI) and into three groups according to change in BMI between 2006 and 2011 (decreased, stable, and increased BMI). Mean values for blood pressure (BP), systolic BP (SBP), diastolic BP (DBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), hemoglobin A1c (HbA1c), and fasting blood glucose (FBG) for each group were determined by sex and subjected to statistical analysis for comparison. Results: High BMI (>26) was associated with higher SBP, LDL-C, FBG, and TG in both sexes. An increase ≥ 1.1 BMI units in 5 years was associated with increased DBP, LDL-C, TG, HbA1c, and FBG and decreased HDL-C. In contrast, decreased BMI was associated with decreased BP and LDL-C and increased HDL-C in both sexes, and decreased TG in men and FBG in women. Conclusions: Maintaining a desirable weight or losing weight may help prevent hypertension and MS, even in non-obese individuals.