Journal Article Protective Effects of Bisoprolol against Acute Exacerbation in Moderate-to-Severe Chronic Obstructive Pulmonary Disease

Taniguchi, Akihiko  ,  Miyahara, Nobuaki  ,  Oda, Naohiro  ,  Morichika, Daisuke  ,  Ichihara, Eiki  ,  Oze, Isao  ,  Tanimoto, Yasushi  ,  Ichikawa, Hirohisa  ,  Fujii, Utako  ,  Tanimoto, Mitsune  ,  Kanehiro, Arihiko  ,  Kiura, Katsuyuki

71 ( 5 )  , pp.453 - 457 , 2017-10 , Okayama University Medical School
Although recent retrospective studies suggested that the use of β-blockers appears to help improve the mortality rate and decrease the rate of exacerbation in chronic obstructive pulmonary disease (COPD) patients with heart failure, the effects of β-blockers on COPD patients without heart failure have not been established. Based on previous reports, we have launched a multicenter, prospective, single-arm phase II study to evaluate the preventive effect of the cardioselective β-blocker bisoprolol in COPD exacerbation, in Japanese individuals with moderate-to-severe COPD who do not have heart failure but do have hypertension requiring the use of medication. The primary endpoint is the rate of mild-to-severe COPD exacerbation. The results of this study will clarify whether bisoprolol can prevent exacerbation in COPD patients without heart failure.

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