Journal Article Genetic Factors of Low-responsiveness to Hepatitis B Virus Vaccine Confirms the Importance of Human Leukocyte Antigen Class II Types in a Japanese Young Adult Population

Yukimasa, Nobuyasu  ,  Kohama, Shota  ,  Oboshi, Wataru  ,  Sato, Shoichi  ,  Nakamura, Takehiro

71 ( 5 )  , pp.433 - 436 , 2017-10 , Okayama University Medical School
We investigated the genetic mechanisms underlying the association between human leukocyte antigen (HLA) types and the immune response to hepatitis B virus (HBV) vaccination in 84 healthy Japanese adults, and found that the HLA-DRB1*04 and HLA-DQB1*03 frequencies were higher in the low responders (<10 mIU/ml; n=9, 10.7%) compared to the responders (≥10 mIU/ml, n=75, 89.3%). The combination of DRB1*04 and DQB1*03 was associated with a low response to vaccination. The DRB1*04 and DQB1*03 haplotypes’ frequencies were significantly higher in the low responders compared to responders. Novel candidate HLA types may be important in Japanese individuals.

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