Journal Article Palladium-Catalyzed Regio- and Stereoselective Carbothiolation of Terminal Alkynes with Azolyl Sulfides

Iwasaki, Masayuki  ,  Topolovčan, Nikola  ,  Hu, Hao  ,  Nishimura, Yugo  ,  Gagnot, Glwadys  ,  nakorn, Rungsaeng Na  ,  Yuvacharaskul, Ramida  ,  Nakajima, Kiyohiko  ,  Nishihara, Yasushi

18 ( 7 )  , pp.1642 - 1645 , 2016-03-21 , American Chemical Society
Palladium-catalyzed carbothiolation of terminal alkynes with azolyl sulfides affords various 2-(azolyl)alkenyl sulfides with perfect regio- and stereoselectivities. The present addition reaction proceeded through a direct cleavage of carbon-sulfur bonds in azolyl sulfides. The resulting adducts that are useful intermediates in organic synthesis are further transformed to multisubstituted olefins containing azolyl moieties.

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