学術雑誌論文 A Case of Refractory Langerhans Cell Histiocytosis Complicated with Hemophagocytic Lymphohistiocytosis Rescued by Cord Blood Transplantation with Reduced-intensity Conditioning

Washio, Kana  ,  Muraoka, Michiko  ,  Kanamitsu, Kiichiro  ,  Oda, Megumi  ,  Shimada, Akira

71 ( 3 )  , pp.249 - 254 , 2017-06 , Okayama University Medical School
ISSN:0386-300X
NII書誌ID(NCID):AA00508441
内容記述
 We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH.
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http://eprints.lib.okayama-u.ac.jp/?locale=en&logined/files/public/5/55208/20170614152850807431/71_3_249.pdf

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