Journal Article Positive Minimal Residual Disease of FLT3-ITD before Hematopoietic Stem Cell Transplantation Resulted in a Poor Prognosis of an Acute Myeloid Leukemia

Iwasaki, Yuka  ,  Nishiuchi, Rituo  ,  Aoe, Michinori  ,  Takahashi, Takahide  ,  Watanabe, Hirokazu  ,  Tokorotani, Chiho  ,  Kikkawa, Kiyoshi  ,  Shimada, Akira

71 ( 1 )  , pp.79 - 83 , 2017-02 , Okayama University Medical School
Acute myeloid leukemia (AML) patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) often have a poor prognosis, even after hematopoietic stem cell transplantation (HSCT). We report a case of AML with FLT3-ITD identified upon initial diagnosis, who received HSCT at complete remission after 3 consecutive chemotherapies. However, the patient relapsed when the same FLT3-ITD clone emerged, and finally died. Retrospective analysis revealed an allelic ratio of FLT3-ITD/wild type of 1.1 and 0.0096 upon initial diagnosis and before HSCT, respectively. The detection of any minimal residual FLT3-ITD clone before HSCT is useful in the treatment of AML with FLT3-ITD.

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