学術雑誌論文 Recurrence after Endoscopic Curative Resection of Mucosal Gastric Cancer Associated with an Adjacent Neoplastic Precursor Lesion

Kikuchi, Satoru  ,  Kagawa, Shunsuke  ,  Ohara, Toshiaki  ,  Kubota, Tetsushi  ,  Kuwada, Kazuya  ,  Kagawa, Tetsuya  ,  Kuroda, Shinji  ,  Shirakawa, Yasuhiro  ,  Nishizaki, Masahiko  ,  Fujiwara, Toshiyoshi

70 ( 3 )  , pp.213 - 216 , 2016-06 , Okayama University Medical School
ISSN:0386-300X
NII書誌ID(NCID):AA00508441
内容記述
A 69-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) at the lesser curvature in the angle of stomach. Histological examination revealed tub1, pM, ly0, v0, pLM(-), pVM(-), and the resection was considered curative. The scar after ESD was followed by esophagogastroduodenoscopy (EGD) and biopsy. Twenty months later, EGD showed an ulcerative lesion in the vicinity of the ESD scar, and histological examination of the biopsy specimen showed adenocarcinoma. A distal gastrectomy with lymph node dissection was then performed. Postoperative pathology showed tub1, pM, pN0, ly0, v0, and Stage 1A. Skip lesions were seen in the specimen resected by ESD, and the histological review confirmed so-called “dysplasia-like atypia” (DLA) between the lesions. It has been reported recently that in DLA, the dysplasia-like change involves only the bases of the pits, without upper pit or surface epithelium involvement, and it is said that the rate of DLA is higher in gastric cancer patients. We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence.
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http://ousar.lib.okayama-u.ac.jp/files/public/5/54421/2016062813473420003/70_3_213.pdf

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