Journal Article Rituximab併用CHOP療法が奏効した肝原発びまん性大細胞型B細胞リンパ腫の1例
A primary diffuse large B-cell lymphoma of the liver treated with R-CHOP regimen

岡田, 博  ,  藤井, 総一郎  ,  渡邉, 謙太郎  ,  重松, 照伸  ,  宮下, 雄博  ,  岡崎, 守宏  ,  小橋, 春彦  ,  横山, 元浩  ,  吉野, 正

127 ( 3 )  , pp.209 - 212 , 2015-12-01 , 岡山医学会
 A 78-year-old Japanese man was referred to our hospital after experiencing black feces. No abnormal finding was detected in the endoscopic examination of his stomach and large intestines. Computed tomography (CT) of the abdomen revealed a tumor lesion in the right lobe of the liver. A needle biopsy of the tumor under ultrasound guidance was performed. A pathological examination of the biopsy specimen showed a diffuse proliferation of lymphoma cells, which was compatible with diffuse large B-cell lymphoma (DLBCL). F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)-CT demonstrated increased FDG uptake only in the liver tumor. We made the diagnosis of primary DLBCL of the liver. After six cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), the patient achieved complete remission and has maintained remission for 2 years since the diagnosis. The R-CHOP regimen might be effective therapy for primary DLBCL of the liver.

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