Departmental Bulletin Paper 成長因子の歯周組織再生療法への応用について
セイチョウ インシ ノ シシュウ ソシキ サイセイ リョウホウ エノ オウヨウ ニツイテ
The application of growth factors for the periodontal regenerative therapy

中村, 利明  ,  ナカムラ, トシアキ  ,  NAKAMURA, Toshiaki

36pp.65 - 74 , 2016-03-25 , 鹿児島大学 , カゴシマ ダイガク , Kagoshima University
Periodontitis is an inflammatory disease resulting in the loss of tooth-supporting tissues including the periodontal ligament, cementum, and alveolar bone, ultimately resulting in tooth loss. Two innovative approaches, guided tissue regeneration and application of enamel matrix derivative, have been found to achieve periodontal regeneration that reproduced essentially normal structure. However, these regenerated tissues were limited to a small part of the damaged area. Thus, further progress is needed in regeneration-based treatment of periodontal disease. So far, several regenerative methods using growth factors including bone morphogenetic proteins (BMPs), platelet-derived growth factor, and basic fibroblast growth factor, have been developed to treat periodontal defects and have achieved favorable results in animal studies and clinical trials. These factors exert their pleiotropic effects, stimulating key events required for periodontal regeneration. Here, I would like to describe the conventional periodontal regenerative therapies, and discussed the application of growth factors including BMP-9 for the periodontal regenerative therapy.

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