紀要論文 Effects of Kampo Formulas on Differentiation and Proinflammatory Cytokines Expression of 3T3-L1 Cells

Qing, YAN  ,  Ogawa, Noriko  ,  Matsumoto, Akihiro  ,  Yuqi, DANG  ,  Otani, Hiroki

34 ( 3 )  , pp.109 - 118 , 2018-03-31 , Faculty of Medicine, Shimane University
ISSN:03865959
NII書誌ID(NCID):AA00841586
内容記述
Effects of Kampo formulas which have been longused clinically for obese patients remain unclear atthe cellular level. The objective of this study is toinvestigate the effects of 8 commonly-used Kamposon the differentiation and proinflammatory cytokinesexpression of 3T3-L1 cells. 3T3-L1 preadipocyteswere induced differentiation being treated with test8 Kampos through the induction period. Oil red Ostaining and mRNAs expressions of peroxisome proliferator-active receptor-γ (PPARγ) and adiponectinwere examined to evaluate effects of the Kamposon the differentiation. Tumor necrosis factor-alpha(TNF-α), interleukin-6, and monocyte chemoattractantprotein-1 (MCP-1) mRNAs were examined toinvestigate the anti-inflammatory effects of the Kampos.PPARγ and/or adiponectin, as well as MCP-1and/or TNF-α mRNAs were significantly decreasedby Boiogito and a few other Kampos when comparedwith the control. These results at the cellularlevel are compatible with the clinical beneficial effectsof these Kampos.
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http://ir.lib.shimane-u.ac.jp/files/public/4/40812/20180409110324734832/Shimane J. Med. Sci.VOL34_no3_P109_118.pdf

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