Departmental Bulletin Paper Two Fatal Cases of Caffeine Poisoning and a Review of the Literatur

Fujihara, Junko  ,  Yasuda, Toshihiro  ,  Kimura-Kataoka, Kaori  ,  Hasegawa, Masanori  ,  Kurata, Satsuki  ,  Takeshita, Haruo

34 ( 2 )  , pp.55 - 59 , 2017-12-31 , Faculty of Medicine, Shimane University
Caffeine is commonly used as a stimulant, and fatalcaffeine overdoses are increasing. In the presentstudy, two case reports showing a fatal blood concentrationof caffeine were reported and comparedto previously published case reports.Case 1: A 19-year-old female was found dead inher room. It was speculated that she ingested 84tablets (100 mg) of a sleep-inhibitor product. Thecaffeine levels in her cardiac blood and stomachwere 116 μg/ml and 619 μg/ml, respectively. Therewas no macroscopic indication of any natural or unnaturalcause of death.Case 2: The condition of a 47-year-old male deterioratedsuddenly. Hypothermia and excess sweatingwere observed. After vomiting several times, he lostconsciousness. At autopsy, severe pulmonary edemawas observed. His cardiac blood caffeine level wasdetermined to be 171 μg/ml, which exceeds fatalblood caffeine levels. However, there is no evidenceof his ingesting massive amounts of caffeine.The blood caffeine concentration in previouslyreported fatal caffeine ingestions ranged from 33 to350 μg/ml. The two present cases are within thisrange. The accumulation of data on blood caffeineconcentrations and ingestion amounts is helpful topredict the intake amount of caffeine.
Full-Text J. Med. Sci.VOL34_no2_P55_P59.pdf

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