Journal Article Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis.

Kessoku, Takaomi  ,  Imajo, Kento  ,  Honda, Yasushi  ,  Kato, Takayuki  ,  Ogawa, Yuji  ,  Tomeno, Wataru  ,  Kato, Shingo  ,  Mawatari, Hironori  ,  Fujita, Koji  ,  Yoneda, Masato  ,  Nagashima, Yoji  ,  Saito, Satoru  ,  和田, 孝一郎  ,  Nakajima, Atsushi

6pp.22251-1 - 22251-11 , 2016 , Nature Publishing Group
The natural polyphenol compound resveratrol (RSV) is considered to have a broad spectrum of beneficial biological activities upon human health. However, the exact effect of RSV on steatosis (a phenotype of non-alcoholic fatty liver [NAFL]) or fibrosis and inflammation (major phenotypes of non-alcoholic steatohepatitis [NASH]) is not known. Our data showed that administration of RSV (2 or 20 mg/kg/day) did not suppress steatosis in a high-fat diet-induced model of NAFL in mice. In contrast, identical concentrations of RSV dramatically inhibited inflammation and fibrosis in a low-dose lipopolysaccharide-induced model of NASH. These data suggested that RSV administration-mediated improvement of inflammation and fibrosis was due to the inhibition of LPS reactivity controlled by CD14 expression in Kupffer cells. These findings suggest that RSV could be a candidate agent for the treatment of NASH.

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