学術雑誌論文 Serum Apolipoprotein M Levels are Correlated with Biomarkers of Coagulation

Yoshida, Kensuke  ,  Kimura, Takao  ,  Shimizu, Tomo  ,  Sato, Koichi  ,  Aoki, Tomoyuki  ,  Sumino, Hiroyuki  ,  Tsunekawa, Katsuhiko  ,  Miyazaki, Osamu  ,  Fukamachi, Isamu  ,  Nakajima, Katsuyuki  ,  Okajima, Fumikazu  ,  Murakami, Masami

66 ( 1 )  , pp.1 - 6 , 2016-02-01 , 北関東医学会
ISSN:1343-2826
NII書誌ID(NCID):AN10585677
内容記述
Background:Apolipoprotein M (ApoM) is bound to high-density lipoprotein (HDL) in plasma, and HDL hasanticoagulation effects. However, the association between ApoM and biomarkers of coagulation was unclear.Therefore, we investigated relationships between ApoM and biomarkers of coagulation.Methods: Serum samples from 233 Japanese participants including with diabetes mellitus, hypertension,dyslipidemia, or healthy controls were analyzed. Serum ApoM levels were measured using Enzyme-LinkedImmuno-Sorbent Assay(ELISA).Results:Analysis of all 233 participants showed that ApoM levels were positively correlated with age (r=0.284,p<0.001), total cholesterol (TC;r=0.477, p<0.001), HDL-cholesterol (HDL-C;r=0.234, p<0.001) and lowdensitylipoprotein cholesterol (LDL-C;r=0.331, p<0.001). Higher ApoM levels were correlated with shorteractivated partial thromboplastin time(APTT;r=-0.226,p=0.001) and prothrombin time(PT,%;r=0.326,p<0.001). Separate analysis of the 115 healthy controls showed that ApoM levels were positively correlated with age,TC, HDL-C and LDL-C, and higher ApoM levels were correlated with shorter PT.Conclusion:Serum levels of ApoM may influence biomarkers of coagulation.
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https://gair.media.gunma-u.ac.jp/dspace/bitstream/10087/9889/1/66_1.pdf

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