Journal Article Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels

Shimizu, Yuji  ,  Sato, Shimpei  ,  Koyamatsu, Jun  ,  Yamanashi, Hirotomo  ,  Nagayoshi, Mako  ,  Kawashiri, Shin-Ya  ,  Inoue, Keita  ,  Fukui, Shoichi  ,  Kondo, Hideaki  ,  Nakamichi, Seiko  ,  Nagata, Yasuhiro  ,  Maeda, Takahiro

23p.16 , 2018-05-03 , BioMed Central Ltd
ISSN:1342078X
Description
Hepatocyte growth factor (HGF) may act as a possible biochemical index for vascular damage, although evidence for the association between HGF and carotid intima-media thickness (CIMT) is limited. Since both HGF and circulating CD34-positive cells play an important role in endothelial repair, circulating CD34-positive cell levels may influence the association between HGF and CIMT. Methods: We conducted a cross-sectional study of 269 elderly Japanese men aged 60-69 years who had undertaken an annual medical checkup from 2014 to 2015. Results: The median value for circulating CD34-positive cells was 0.93 cells/μL. Among the study population, 135 men showed low circulating CD34-positive cell levels (≤ 0.93 cells/μL). By multivariable linear regression analysis, HGF was found to be significantly positively associated with CIMT only to participants with low circulating CD34-positive cell levels, with a multi-adjusted β of 0.26 (p = 0.005) and 0.002 (0.986) for low and high circulating CD34-positive cell levels, respectively. In addition, a significant interaction was observed between HGF and circulating CD34-positive cell levels (low and high) on CIMT (multivariable p value of 0.049). A positive association exists between HGF and CIMT in elderly Japanese men, limited to participants with low circulating CD34-positive cell levels. Conclusion: A positive association exists between HGF and CIMT in community-dwelling elderly Japanese men, which is limited to participants with low numbers of circulating CD34-positive cells. Our findings indicate that circulating CD34-positive cell levels could determine the influence of HGF on CIMT in elderly Japanese men.
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http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/38299/1/EHPM23_16.pdf

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