Journal Article Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese

Shimizu, Yuji  ,  Sato, Shimpei  ,  Koyamatsu, Jun  ,  Yamanashi, Hirotomo  ,  Nagayoshi, Mako  ,  Kadota, Koichiro  ,  Kawashiri, Shin-Ya  ,  Inoue, Keita  ,  Nagata, Yasuhiro  ,  Maeda, Takahiro

8 ( 41 )  , pp.69362 - 69369 , 2017-09-01 , Impact Journals LLC
Description
Age-related disruption of microvascular endothelium exacerbates hypertension and sarcopenia; and atherosclerosis is a well-known biological response to vascular endothelial injury. Therefore, prevalence of atherosclerosis among hypertensive elderly subjects may partly indicate the presence of an appropriate response to endothelial injury. We conducted a cross-sectional study of 795 elderly hypertensive Japanese subjects aged 60-89 years. Since platelet level is an indicator of vascular repair activity, subjects were stratified by platelet counts. No significant association between handgrip strength and subclinical carotid atherosclerosis (carotid intima-media thickness (CIMT) ≥1.1mm) was observed for subjects with lower platelet counts, while a significant positive association was observed for subjects with higher platelets. Adjusted odds and 95% confidence intervals of subclinical carotid atherosclerosis for 1 standard deviation increments in handgrip strength were 0.86 (0.61, 1.22) for subjects with lower platelets and 1.82 (1.26, 2.64) for subjects with higher platelets. A positive association between handgrip strength and subclinical carotid atherosclerosis exists in hypertensive elderly subjects with higher, but not lower, platelet counts. These results lead us to speculate that subjects with a beneficial influence on prevention of sarcopenia (maintenance of handgrip strength) may possess the capacity of active endothelial repair that causes atherosclerosis.
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http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/37863/1/Onco8_69362.pdf

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