学術雑誌論文 Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels

Shimizu, Yuji  ,  Sato, Shimpei  ,  Koyamatsu, Jun  ,  Yamanashi, Hirotomo  ,  Nagayoshi, Mako  ,  Kadota, Koichiro  ,  Kawashiri, Shin-Ya  ,  Maeda, Takahiro

36p.26 , 2017-06-15 , 日本生理人類学会
内容記述
Background: Although high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor. Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension. Methods: To investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60–69 years who participated in general health checkup. Results: HDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. Known cardiovascular risk factors adjusted odds (ORs) and 95% confidence intervals (CIs) of hypertension for increments of one standard deviation (SD) in HDL (13.8 mg/dL) were 1.44 (1.06, 1.96) for subjects with a high level of circulating CD34-positive cells and 0.87 (0.63, 1.19) for subjects with low circulating CD34-positive cells. We also revealed a significant association between HDL level and CD34-positive cell level on hypertension, with fully adjusted p values for the effect of this interaction on hypertension at 0.022. Conclusions: Independent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells.
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http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/37783/1/JPA36_26.pdf

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