Journal Article High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature

Itonaga, Hidehiro  ,  Kato, Takeharu  ,  Fujioka, Machiko  ,  Taguchi, Masataka  ,  Taniguchi, Hiroaki  ,  Imaizumi, Yoshitaka  ,  Yoshida, Shinichiro  ,  Miyoshi, Hiroaki  ,  Moriuchi, Yukiyoshi  ,  Ohshima, Koichi  ,  Miyazaki, Yasushi

56 ( 14 )  , pp.1873 - 1877 , 2017-07-15 , 日本内科学会
An adult woman developed polymorphic post-transplant lymphoproliferative disorder (PTLD) 58 months after unrelated cord blood transplantation. She was treated successfully with chemotherapy and radiation therapy but presented with lymphadenopathy and splenomegaly 74 months after transplantation. A lymph node biopsy confirmed the diagnosis of nodular sclerosis type Hodgkin lymphoma (classical Hodgkin lymphoma [CHL]-type PTLD). After salvage therapy and hematopoietic stem cell harvesting, she was subsequently treated with consolidative high-dose chemotherapy with melphalan followed by stem cell rescue, which resulted in durable remission. High-dose chemotherapy using stem cell rescue has potential as a therapeutic option for subsequent CHL-type PTLD.

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