Journal Article 3,3-Dibromo-2-trifluoromethyl acrylic acid ethyl ester: a versatile platform for the stereoselective preparation of functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones

Mizuta, Satoshi  ,  Otaki, Hiroki  ,  Kitamura, Kanami  ,  Nishi, Kodai  ,  Watanabe, Ken  ,  Makau, Juliann Nzembi  ,  Hashimoto, Ryo  ,  Usui, Toshiya  ,  Chiba, Kenya

3 ( 12 )  , pp.1661 - 1667 , 2016-12 , Royal Society of Chemistry
Description
We herein describe a method for synthetic routes to multi-functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones. This involves a tandem stereoselective functionalization of 3,3-dibromo-2-trifluoromethyl acrylic acid ethyl ester and intramolecular cyclization reaction to afford precursors for a Suzuki-Miyaura cross-coupling reaction with arylboronic acids.
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http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/37368/1/OCF3_1661.pdf

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