学術雑誌論文 Synthesis and Antimicrobial Activity of Nitrobenzyl-oxy-phenol Derivatives

Mohamed, Malik Suliman  ,  Maki, Toshihide  ,  Shah, Mohammad Monir  ,  Ichinose, Yoshio

39 ( 11 )  , pp.1888 - 1892 , 2016-11-01 , 日本薬学会
ISSN:09186158
内容記述
Two hydroquinone derivatives were prepared and their antimicrobial activity evaluated. Their minimum inhibitory concentrations (MICs) were determined using a broth dilution method. Gentamycin and ciprofloxacin were used as reference antibiotics. The antimicrobial activity of 4-(benzyloxy)phenol (monobenzone) was also evaluated based on its structural similarity to the new compounds; activity was comparable to that of 3,5-dimethyl-4-((4-nitrobenzyl)oxy)phenol (4a). 2,3,5-Trimethyl-4-((4-nitrobenzyl)oxy)phenol (4b) exhibited the best antibacterial activity against both clinical isolates and type strain of Moraxella catarrhalis (M. catarrhalis), with a MIC value of 11 μM, comparable to ciprofloxacin 9 μM.
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http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/37351/1/BPBul39_1888.pdf

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