Effect of scavenging circulating reactive carbonyls by oral pyridoxamine in uremic rats on peritoneal dialysisEffect of scavenging circulating reactive carbonyls by oral pyridoxamine in uremic rats on peritoneal dialysis 尿毒症ラットの腹膜透析に対する、経口ピリドキサミンの活性カルボニル消去効果
654 , 2016-12-07 , International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy
Pyridoxamine, a reactive carbonyl (RCO) scavenger, can ameliorate peritoneal deterioration in uremic peritoneal dialysis (PD) rats when given via dialysate. We examined the effects of scavenging circulating RCOs by oral pyridoxamine. Rats underwent nephrectomy and 3 weeks of twice daily PD either alone or with once daily oral pyridoxamine. PD solution was supplemented with methylglyoxal, a major glucose-derived RCO, to quench intraperitoneal pyridoxamine. Oral pyridoxamine achieved comparable blood and dialysate pyridoxamine concentrations, suppressed pentosidine
accumulation in the blood but not in the mesenterium or dialysate, and reduced the increases in small solute transport and mesenteric vessel
densities, with no effects on submesothelial matrix layer thickening or serum creatinine. Thus, reducing circulating RCOs by giving oral pyridoxamine with PD provides limited peritoneal protection. However, orally given pyridoxamine efficiently reaches the peritoneal cavity and would
eliminate intraperitoneal RCOs. Oral pyridoxamine is more clinically favorable and may be as protective as intraperitoneal administration.