Incidence of and risk factors for bile duct stones after living donor liver transplantation: An analysis of 100 patientsIncidence of and risk factors for bile duct stones after living donor liver transplantation: An analysis of 100 patients 生体肝移植後の胆管結石の罹患率と危険因子についての検討
Aim: Although bile duct stone (BDS) is one of the biliary complications of liver transplantation, analytical studies, particularly on living donor liver transplantation (LDLT) cases, are rare. This
study aimed to clarify the incidence of and risk factors for BDS following LDLT. Methods: We retrospectively reviewed the medical records of 100 patients who underwent LDLT at our institute from August 2000 to May 2012, and analyzed their clinical characteristics and risk factors for BDS. Results: Of these, 10 patients (10.0%) developed BDS during the observation period. The median follow-up period to BDS diagnosis was 45.5 months (range, 5–84) after LDLT. Univariate analysis revealed male sex, right lobe graft and bile duct strictures as factors that significantly correlated with BDS formation. Multivariate analysis revealed bile duct strictures (odds ratio, 7.17; P = 0.011) and right lobe graft (odds ratio, 10.20; P = 0.040) to be independent risk factors for BDS formation. One patient with BDS and biliary strictures succumbed to sepsis from cholangitis. Conclusion: In the present study, right lobe graft and bile duct strictures are independent risk factors for BDS formation after LDLT. More careful observation and monitoring are required in the patients with high-risk factors.
bile duct stone complication living donor liver transplantation male sex right lobe graft
Wiley Publishing Asia Pty Ltd
Thesis or Dissertation
Nagasaki University (長崎大学), 博士(医学) (2016-03-18)
(C) 2014 The Japan Society of Hepatology This is the peer reviewed version of the following article: Hepatology Research, 45(9), pp.969-975; 2015, which has been published in final form at http://dx.doi.org/10.1111/hepr.12438. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.