Thesis or Dissertation Upregulation of thrombospondin-1(TSP-1) expression in synovial tissues and plasma of rheumatoid arthritis (RA): Role of transforming growth factor-β1 toward fibroblast-like synovial cells

鈴木, 貴久

42 ( 6 )  , pp.943 - 947 , 2015-03-20 , The Journal of Rheumatology Publishing Company Limited
ISSN:0315162X
Description
Objective: To investigate the role of thrombospondin 1 (TSP-1) in RA. Methods: Expression of TSP-1 in synovial tissues was determined by immunohistochemistry. Expression of TSP-1 in rheumatoid fibroblast-like synovial cells (FLS) was investigated by quantitative real-time PCR and ELISA. Correlations among the plasma TSP-1 and other variables in patients with RA were examined. Results: Expression of TSP-1 was increased in rheumatoid synovial tissues. Transforming growth factor-β1 (TGF-β1) clearly increased TSP-1 expression in FLS on both mRNA and protein levels. Changes in plasma TSP-1 were associated with those in 28-joint Disease Activity Score-erythrocyte sedimentation rate and plasma TGF-β1. Conclusion: TSP-1 might be critically involved in the disease process of RA through the TGF-β1/TSP-1 axis.
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