Departmental Bulletin Paper Quantitative Features of serum sIL-2R level in Patients with Mature B-Cell Lymphoma– Involvement of LDH

Matsumoto, Reiko  ,  Kamihira, Shimeru  ,  Matsubara, Takashi  ,  Yamada, Shouichi  ,  Matsuda, Kazuyuki  ,  Kinoshita, Kazuhisa  ,  Takahashi, Youichi  ,  Kanematsu, Takashi  ,  Nakashima, Kazuhisa  ,  De Kerckhove, Charles

60 ( 2 )  , pp.33 - 37 , 2016-01 , Nagasaki University School of Medicine
Serum Lactate Dehydrogenase (LDH) activity and soluble IL-2 Receptor-alpha (sIL-2R) levels are monitored as a marker of disease activity in patients with lymphoma. Although adult T-cell leukemia (ATL) cells are well known to release large amounts of sIL-2R,it remains unclear to what extent B-cell lymphoma cells shed sIL-2R in sera. Subtypes of mature B-cell lymphoma, including CD25+ hairy leukemic cells, were examined for the characteristics of sIL-2R levels in each subtype. In normal controls, the serum sIL-2R mean value was 260u/mL.The median serum sIL-2R value for 64 B-cell lymphoma cases was 506 u/mL;by subtype the median values were as follows: 1157 u/mL for 7 cases of chronic lymphocytic leukemia/hairy cell leukemia (CLL/HCL), 451 u/mL for 38 cases of diffuse large B-cell lymphoma (DLBCL), and 456 u/mL for 19 cases of follicular Lymphoma (FL). The median values of serum LDH activity by the above subtypes were 175 IU/mL, 204 IU/mL, and 198 IU/mL, respectively. There was distinct inter-subtype and inter-patient variation of serum sIL-2R.In particular, inter-case variation could be grouped into value for three concentration ranges: less than 300 u/mL, 300-1000 u/mL, and greater than 1000 u/mL. Cases with serum sIL-2R values of 1000 u/mL or more tended to have an especially high sIL-2R to LDH ratio, suggesting a close relationship between high sIL-2R and CD25-expressing lymphoma cells. With respect to sIL-2R and LDH levels, CLL/HCL, DLBCL, and FL showed similar distributions. Moreover, for sIL-2R levels exceeding 1000u/mL, sIL-2R levels were randomly high according to the LDH status. Conclusively, the combination of serum sIL-2R level and LDH activity can provide a better understanding of characteristics of subtypes of mature B-Cell Lymphoma and can be used as a reliable surrogate marker for evaluating numerical and biological data.

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