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Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese populationLack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population |
"/Migita, Kiyoshi(1000060264214)/"Migita, Kiyoshi
,
"/Jiuchi, Yuka/"Jiuchi, Yuka ,
"/Furukawa, Hiroshi/"Furukawa, Hiroshi ,
"/Nakamura, Minoru(1000040217906)/"Nakamura, Minoru
,
"/Komori, Atsumasa/"Komori, Atsumasa ,
"/Yasunami, Michio/"Yasunami, Michio ,
"/Kozuru, Hideko/"Kozuru, Hideko ,
"/Abiru, Seigo/"Abiru, Seigo ,
"/Yamasaki, Kazumi/"Yamasaki, Kazumi ,
"/Nagaoka, Shinya/"Nagaoka, Shinya ,
"/Hashimoto, Satoru/"Hashimoto, Satoru ,
"/Bekki, Shigemune/"Bekki, Shigemune ,
"/Yoshizawa, Kaname/"Yoshizawa, Kaname ,
"/Shimada, Masaaki/"Shimada, Masaaki ,
"/Kouno, Hiroshi/"Kouno, Hiroshi ,
"/Kamitsukasa, Hiroshi/"Kamitsukasa, Hiroshi ,
"/Komatsu, Tatsuji/"Komatsu, Tatsuji ,
"/Hijioka, Taizo/"Hijioka, Taizo ,
"/Nakamuta, Makoto/"Nakamuta, Makoto ,
"/Naganuma, Atsushi/"Naganuma, Atsushi ,
"/Yamashita, Haruhiro/"Yamashita, Haruhiro ,
"/Nishimura, Hideo/"Nishimura, Hideo ,
"/Ohta, Hajime/"Ohta, Hajime ,
"/Nakamura, Yoko/"Nakamura, Yoko ,
"/Ario, Keisuke/"Ario, Keisuke ,
"/Oohara, Yukio/"Oohara, Yukio ,
"/Sugi, Kazuhiro/"Sugi, Kazuhiro ,
"/Tomizawa, Minoru/"Tomizawa, Minoru ,
"/Sato, Takeaki/"Sato, Takeaki ,
"/Takahashi, Hironao/"Takahashi, Hironao ,
"/Muro, Toyokichi/"Muro, Toyokichi ,
"/Makita, Fujio/"Makita, Fujio ,
"/Mita, Eiji/"Mita, Eiji ,
"/Sakai, Hironori/"Sakai, Hironori ,
"/Yatsuhashi, Hiroshi/"Yatsuhashi, Hiroshi
8p.777 , 2015-12-12 , BioMed Central
Description
Background: Previous genome-wide association studies have evaluated the impact of common genetic variants and identified several non-HLA risk loci associated with autoimmune liver diseases. More recent genome-wide association studies and replication analyses reported an association between variants of the CARD10 polymorphism rs6000782 and risk of type 1 autoimmune hepatitis (AIH). In this case-control study, we genotyped 326 Japanese AIH patients and 214 control subjects. Results: Genomic DNA from 540 individuals of Japanese origin, including 326 patients with type-1 AIH and 214 healthy controls, was analyzed for two single nucleotide polymorphisms (SNPs) in the CARD10 gene. We selected CARD10 rs6000782 SNPs and genotyped these using PCR-RFLP method and direct sequencing. The Chi square test revealed that the rs6000782 variant alle (c) was not associated with the susceptibility for AIH in a Japanese population [p = 0.376, odds ratio (OR) 1.271, 95 % confidence interval (CI) 0.747-2.161] in an allele model. Our data also showed that CARD10 rs6000782 variants were not associated with AIH or with the clinical parameters of AIH. Conclusions: In this study we examined an association between rs6000782 SNPs in the CARD10 gene and type-1 AIH. Results showed no significant association of rs62000782 with type-1 AIH in a Japanese population. This study demonstrated no association between CARD10 rs6000782 variants and AIH in a Japanese population.
Full-Text
http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/36132/1/BMCRN8_777.pdf