Journal Article Active Surveillance of Methicillin-Resistant Staphylococcus aureus Using a Fully Automated Molecular Test in an Emergency Medical Center

Morinaga, Yoshitomo  ,  Yamano, Shuhei  ,  Akamatsu, Norihiko  ,  Kaku, Norihito  ,  Nagaoka, Kentaro  ,  Migiyama, Yohei  ,  Harada, Yosuke  ,  Hosogaya, Naoki  ,  Yamamoto, Yoshihiro  ,  Tasaki, Osamu  ,  Yanagihara, Katsunori  ,  Kohno, Shigeru

68 ( 5 )  , pp.376 - 380 , 2015-09-19 , 国立感染症研究所
The prevention and control of methicillin-resistant Staphylococcus aureus (MRSA) are important, particularly in emergency units. The active surveillance of MRSA was prospectively performed at the emergency medical center of Nagasaki University Hospital. After obtaining nasal swab specimens, a fully automated molecular test (FAMT) and a culture-screening method were utilized for MRSA detection. A total of 150 patients were enrolled in the study, and 366 nasal swab specimens were obtained. MRSA was detected by culture in 11 (7.3%) patients including one new acquisition and by the FAMT in 34 (22.7%) patients including 13 new acquisitions. The sensitivity, specificity, positive predictive value, and negative predictive value of the FAMT at the patient level were 86.7, 85.2, 39.4, and 98.3%, respectively, when compared with the culture-based results. An FAMT can effectively detect MRSA colonization, which may remain undetected with the conventional method, and it may be useful in detecting newly acquired MRSAs.

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