Journal Article Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Values Predict the Development of Hepatocellular Carcinoma among Patients with Chronic Hepatitis C after Sustained Virological Response

Sasaki, Ryu  ,  Yamasaki, Kazumi  ,  Abiru, Seigo  ,  Komori, Atsumasa  ,  Nagaoka, Shinya  ,  Saeki, Akira  ,  Hashimoto, Satoru  ,  Bekki, Shigemune  ,  Kugiyama, Yuki  ,  Kuno, Atsushi  ,  Korenaga, Masaaki  ,  Togayachi, Akira  ,  Ocho, Makoto  ,  Mizokami, Masashi  ,  Narimatsu, Hisashi  ,  Ichikawa, Tatsuki  ,  Nakao, Kazuhiko  ,  Yatsuhashi, Hiroshi

10 ( 6 )  , p.e0129053 , 2015-06-12 , Public Library of Science
Description
Measurement of Wisteria floribundaagglutinin-positive human Mac-2 binding protein (WFA+-M2BP) in serum was recently shown to be a noninvasive method to assess liver fibrosis. The aim of this study was to evaluate the utility of serum WFA+-M2BP values to predict the development of hepatocellular carcinoma (HCC) in patients who achieved a sustained virological response (SVR) by interferon treatment. For this purpose, we retrospectively analyzed 238 patients with SVR who were treated with interferon in our department. Serum WFA+-M2BP values were measured at pre-treatment (pre-Tx), post-treatment (24 weeks after completion of interferon; post-Tx), the time of HCC diagnosis, and the last clinical visit. Of 238 patients with SVR, HCC developed in 16 (6.8%) patients. The average follow-up period was 9.1 years. The cumulative incidence of HCC was 3.4% at 5 years and 7.5% at 10 years. The median pre-Tx and post-Tx WFA+-M2BP values were 1.69 (range: 0.28 to 12.04 cutoff index (COI)) and 0.80 (range: 0.17 to 5.29 COI), respectively. The WFA+-M2BP values decreased significantly after SVR (P < 0.001). The median post-Tx WFA+-M2BP value in patients who developed HCC was significantly higher than that in patients who did not (P < 0.01). Multivariate analysis disclosed that age (> 60 years), sex (male), pre-Tx platelet count (< 15.0×103/μL), and post-Tx WFA+-M2BP (> 2.0 COI) were associated with the development of HCC after SVR. Conclusion: Post-Tx WFA+-M2BP (> 2.0 COI) is associated with the risk for development of HCC among patients with SVR. The WFA+-M2BP values could be a new predictor for HCC after SVR.
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http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/35722/1/PLoS10_129053.pdf

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