学術雑誌論文 Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats

Han, Chong  ,  Inaba, Wataru  ,  Yonekura, Manabu  ,  Ogata, Yoshiki  ,  Ohba, Takayoshi  ,  Kushikata, Tetsuya  ,  Niwa, Hidetoshi  ,  Yanagisawa, Teruyuki  ,  Tomita, Hirofumi  ,  Itagaki, Shirou  ,  Hirota, Kazuyoshi  ,  Akai, Hiroaki  ,  Mizukami, Hiroki  ,  Murakami, Manabu

68 ( 1 )  , pp.33 - 43 , 2017-10-05 , 弘前大学大学院医学研究科・弘前医学会
ISSN:0439-1721
NII書誌ID(NCID):AN00211444
内容記述
 Persistent hyperglycemia is implicated in the pathogenesis of chronic diabetic complications, such asneuropathy. Therefore, we investigated Electrocardiogram( ECG)-related changes, including various ECG parametersand heart rate variability, and neuropathic changes in diabetic Goto-Kakizaki (GK) rats, a spontaneous model fortype 2 diabetes. GK rats (50 weeks old) showed increased plasma glucose and decreased R-R interval variability,which was likely due to diabetic polyneuropathy in the autonomic nervous system. Interestingly, GK rats showed adecreased baroreflex compared with control Wistar rats. Furthermore, GK rats showed limited fluctuation changesin beat-to-beat dynamics. In the frequency domain analysis, the low-frequency component was similar but the highfrequencycomponent was significantly decreased in GK rats, suggesting decreased parasympathetic nerve regulationand conserved sympathetic nerve regulation. In addition, GK rats showed a limited response to high-dose atropine, amuscarinic receptor antagonist, indicating modified parasympathetic nerve regulation in GK rats. Our data stronglysuggests that GK rat could be a nice animal model for chronic cardiovascular disease related to diabetic neuropathy.
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http://repository.ul.hirosaki-u.ac.jp/dspace/bitstream/10129/6146/1/HirosakiMedJ_68%281%29_33.pdf

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