Journal Article Association of Sex Steroid Hormones wth Neutrophil Function in the General Population

Sato, Satoshi  ,  Komame, Hitomi  ,  Akimoto, Naoki  ,  Sawada, Kaori  ,  Tanaka, Rina  ,  Munakata, Osamu  ,  Iizuka, Hiroshi  ,  Shibata, Nobuyuki  ,  Nakaji, Shigeyuki

67 ( 1 )  , pp.13 - 27 , 2016-07-29 , 弘前大学大学院医学研究科・弘前医学会
There are certain sex differences in the prevalence and severity of immunity-related diseases. Previousstudies have shown the influence of sex steroid hormones, such as estrogen and testosterone, on the immune system.The aim of this study was to investigate the association of sex steroid hormones with neutrophil function amongnormal healthy subjects in the general population. Subjects included 540 residents( 358 males and 182 females), whoparticipated in the Iwaki Health Promotion Project in 2014. We examined the association of estradiol and testosteronewith neutrophil ROS production and phagocytic activity. As a result, estradiol and testosterone negatively correlatedwith basal ROS production in males and luteal phase females (>15th day of menstrual cycle), although such trendwas not observed in follicular phase females( <14th day of menstrual cycle) and postmenopausal females. In contrast,the association of testosterone with stimulated ROS production and phagocytic activity was observed only in males.In conclusion, both estradiol and testosterone were found to have an influence on neutrophil function. Furthermore,the association of sex steroid hormones with neutrophil function was found to vary according to the phase of the menstrual cycle in addition to the sex difference.

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