Departmental Bulletin Paper 無脊椎動物神経系を用いた非連合学習の分子メカニズムの解明
ムセキツイ ドウブツ シンケイケイ オ モチイタ ヒレンゴウ ガクシュウ ノ ブンシ メカニズム ノ カイメイ
Investigation of the molecular mechanisms of non-associative learning of the earthworm

北村, 美一郎||キタムラ, ヨシイチロウ

59pp.7 - 12 , 2016-03 , 関東学院大学工学会
ISSN:03685373
NCID:AN00045764
Description
Molecular mechanisms of non-associative learning (habituation) in the earthworm Eisenia fetida was investigated. With extracellular recording from the ventral nerve cord of the earthworm, it is revealed that number of action potentials occurred in the median giant fiber decreased after repeated tactile stimulus to the body wall. This inhibition of neural activity is assumedly due to via nitric oxide (NO)-cyclic GMP (cGMP) signaling, because NO donor and cGMP analogue also decreased the number of action potentials by single tactile stimulus. Interestingly, not only cGMP analogue but also guanylate cyclase inhibitor decreased the number of action potentials by single tactile stimulus. These results indicate that cGMP has an excitatory effect on action potential generation, though excess of cGMP reduced the responsibility to tactile stimulus. In conclusion, NO-induced-cGMP has a bi-directional effect on neural activity by tactile stimulus to the body wall of the earthworm, and the non-associative learning such as habituation is possibly formed due to cGMP accumulation.
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http://library.kanto-gakuin.ac.jp/e-Lib/bdyview.do?bodyid=NI30001052&elmid=Body&lfname=link/002.pdf

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