学術雑誌論文 The IGF-1/Akt/S6 pathway and expressions of glycolytic myosin heavy chain isoforms are upregulated in chicken skeletal muscle during the first week after hatching

Saneyasu, Takaoki  ,  Tsuchihashi, Tatsuya  ,  Kitashiro, Ayana  ,  Tsuchii, Nami  ,  Kimura, Sayaka  ,  Honda, Kazuhisa  ,  Kamisoyama, Hiroshi

88 ( 11 )  , pp.1779 - 1787 , 2017-11 , Wiley
ISSN:1344394117400929
内容記述
Skeletal muscle mass is an important trait in the animal industry. We previously reported an age-dependent downregulation of the insulin‐like growth factor 1 (IGF‐1)/Akt/S6 pathway, major protein synthesis pathway, in chicken breast muscle after 1 week of age, despite a continuous increase of breast muscle weight. Myosin heavy chain (HC), a major protein in muscle fiber, has several isoforms depending on chicken skeletal muscle types. HC I (fast-twitch glycolytic type) is known to be expressed in adult chicken breast muscle. However, little is known about the changes in the expression levels of protein synthesis-related factors and HC isoforms in perihatching chicken muscle. In the present study, protein synthesis-related factors, such as IGF-1 messenger RNA (mRNA) levels, phosphorylation of Akt, and phosphorylated S6 content, increased in an age-dependent manner after post-hatch day (D) 0. The mRNA levels of HC I, III and V (fast‐twitch glycolytic type) dramatically increased after D0. The increase ratio of breast muscle weight was approximately 1100% from D0 to D7. To our knowledge, these findings provide the first evidence that upregulation of protein synthesis pathway and transcription of fast twitch glycolytic HC isoforms play critical roles in the increase of chicken breast muscle weight during the first week after hatching.
本文を読む

http://www.lib.kobe-u.ac.jp/repository/90004617.pdf

このアイテムのアクセス数:  回

その他の情報