学術雑誌論文 Low amounts of dietary fibre increase in vitro production of short-chain fatty acids without changing human colonic microbiota structure

Sasaki, Daisuke  ,  Sasaki, Kengo  ,  Ikuta, Naoko  ,  Yasuda, Takahiro  ,  Fukuda, Itsuko  ,  Kondo, Akihiko  ,  Osawa, Ro

8p.435 , 2018-01-11 , Nature Publishing Group
ISSN:2045232220452322
内容記述
This study investigated the effect of various prebiotics (indigestible dextrin, α-cyclodextrin, and dextran) on human colonic microbiota at a dosage corresponding to a daily intake of 6g of prebiotics per person (0.2% of dietary intake). We used an in vitro human colonic microbiota model based on batch fermentation starting from a faecal inoculum. Bacterial 165 rRNA gene sequence analysis showed that addition of 0.2% prebiotics did not change the diversity and composition of colonic microbiota. This finding coincided with results from a clinical study showing that the microbiota composition of human faecal samples remained unchanged following administration of 6g of prebiotics over seven days. However, compared to absence of prebiotics, their addition reduced the pH and increased the generation of acetate and propionate in the in vitro system. Thus, even at such relatively low amounts, prebiotics appear capable of activating the metabolism of colonic microbiota.
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http://www.lib.kobe-u.ac.jp/repository/90004603.pdf

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