学位論文 Effect of e-beam sterilization on the in vivo performance of conventional UHMWPE tibial plates for total knee arthroplasty

Tone, Shine

2017-09-20 , 三重大学
内容記述
Although the introduction of highly cross-linked polyethylene is effective in reducing the amount of wear, there are still major concerns regarding the use of this material in total knee arthroplasty (TKA), essentially due to the reduction of fatigue resistance and toughness. Monitoring the in vivo performance of different types of UHMWPE is a much needed task to tackle the lack of information on which should be the most reliable choice for TKA. The present study was aimed at investigating the mid-term degradation of electron beam sterilized conventional UHMWPE tibial plates. Visual inspection enabled to grade the surface damage of 12 retrievals according to the Hood’s score: the total wear damage correlates to the in vivo time (Spearman’s q = 0.681, p < 0.05) and BMI (q = 0.834, p < 0.001). Surface degradation was less severe than that quantified in similar studies on c-sterilized UHMWPE. Raman and infra-red spectroscopies were utilized to unfold the microstructural modifications. In the load zone, polyethylene whitened damage regions were noticed in the inserts implanted longer than 1 year, in which oxidation index (OI) is clearly higher than 1 (max 8). The maximum OI (q = 0.802, p < 0.005) and ac (q = 0.816, p < 0.005) correlate to the implantation time in the load zone. The crystallinity increased along with the extent of oxidation. Concentration of absorbed species from synovial fluid is higher in the contact zone and correlates to maximum OI (Spearman’s q = 0.699, p = 0.011). Absorption was promoted in the contact area by the mechanical action of the femoral counterpart and it exacerbated the oxidative degradation in retrievals with high concentration of absorbed species. In the non-load zone, mild but detectable oxidation was observed, probably due to free radicals trapped after sterilization.
本文 / Department of Orthopaedic Surgery, Mie University, Graduate School of Medicine
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