Research Paper 白血病微小環境(骨髄及び中枢神経系)におけるN―カドヘリン分子機構の解明

岩本, 彰太郎  ,  平山, 雅浩  ,  IWAMOTO, Shotaro  ,  HIRAYAMA, Masahiro

2015-05-19 , 三重大学
N-cadherin, a family of Ca2+-dependent intercellular adhesion molecules, plays key roles in controlling morphogenetic movements during development and hematopoiesis in bone marrow (BM). Recently, it has been reported that this molecule might be associated with drug resistance in adult leukemia. Then we studied the clinical significance of N-cadherin in BM niche in acute childhood leukemia. We found that N-cadherin was highly expressed on primary / hTERT immortalized BM stroma cells (BMSCs). Several kinds of leukemic cell lines and primary childhood leukemia cells also expressed different levels of N-cadherin. In addition, drug sensitivity in leukemic cells for anti-leukemic agents in co-culture system between leukemic cells and BMSCs increased in the presence of GC-4 antibody that can inhibit N-cadherin adherens junction formation .Taken together, these results supported that N-cadherin might be related to drug resistance in childhood acute leukemic cells in BM microenvironments.

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