||Solid-Phase Modular Synthesis of Park Nucleotide and Lipids I and II Analogues
Katsuyama, Akira ,
Sato, Kousuke ,
Yakushiji, Fumika ,
Matsumaru, TakanoriIchikawa, Satoshi
Chemical & pharmaceutical bulletin
95 , 2018-01 , The Pharmaceutical Society of Japan （日本薬学会）
A solid-phase synthesis of Park nucleotide as well as lipids I and II analogues, which is applicable to the synthesis of a range of analogues, is described in this work. This technique allows highly functionalized macromolecules to be modularly labeled. Multiple steps are used in a short time (4d) with a single purification step to synthesize the molecules by solid-phase synthesis.