学術雑誌論文 Synthesis of Fluorine-Containing 6-Arylpurine Derivatives Cp*Co(III)-Catalyzed C-H Bond Activation

Murakami, Nanami  ,  Yoshida, Misaki  ,  Yoshino, Tatsuhiko  ,  Matsunaga, Shigeki

66 ( 1 )  , pp.51 - 54 , 2018-01 , The Pharmaceutical Society of Japan (日本薬学会)
ISSN:0009-2363
内容記述
Cp*Co(III)-catalyzed (Cp*=pentamethylcyclopentadienyl) C-H bond functionalization of 6-arylpurines using gem-difluoroalkenes and allyl fluorides is described. The reaction with gem-difluoroalkenes afforded monofluoroalkenes with high (Z)-selectivity, while the reaction with allyl fluorides led to C-H allylation in moderate (Z)-selectivity. Both reactions proceeded using a user-friendly single-component catalyst [Cp*Co(CH3CN)(3)](SbF6)(2) in fluorinated alcohol solvents without any additives. Robustness was also demonstrated by a preparative-scale reaction under air.
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https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/68309/1/WoS_81829_Matsunaga.pdf

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