||Synthesis of Fluorine-Containing 6-Arylpurine Derivatives Cp*Co(III)-Catalyzed C-H Bond Activation
Murakami, Nanami ,
Yoshida, Misaki Yoshino, Tatsuhiko ,
Chemical & pharmaceutical bulletin
54 , 2018-01 , The Pharmaceutical Society of Japan （日本薬学会）
Cp*Co(III)-catalyzed (Cp*=pentamethylcyclopentadienyl) C-H bond functionalization of 6-arylpurines using gem-difluoroalkenes and allyl fluorides is described. The reaction with gem-difluoroalkenes afforded monofluoroalkenes with high (Z)-selectivity, while the reaction with allyl fluorides led to C-H allylation in moderate (Z)-selectivity. Both reactions proceeded using a user-friendly single-component catalyst [Cp*Co(CH3CN)(3)](SbF6)(2) in fluorinated alcohol solvents without any additives. Robustness was also demonstrated by a preparative-scale reaction under air.