学術雑誌論文 Enantioselective synthesis of beta-amino acid derivatives via nickel-promoted regioselective carboxylation of ynamides and rhodium-catalyzed asymmetric hydrogenation

Saito, Nozomi  ,  Abdullah, Iman  ,  Hayashi, Kayoko  ,  Hamada, Katsuyuki  ,  Koyama, Momoko  ,  Sato, Yoshihiro

14 ( 42 )  , pp.10080 - 10089 , 2016-11-14 , Royal Society of Chemistry
ISSN:1477-0520
内容記述
We succeeded in the development of a new method for enantioselective synthesis of alpha-substituted-beta-amino acid derivatives. Thus, nickel(0)-promoted carboxylation of ynamide gave the alpha-substituted-beta-aminoacrylate derivative in a highly regioselective manner. Then, rhodium-catalyzed asymmetric hydrogenation of the a-substituted beta-aminoacrylate produced the corresponding alpha-substituted beta-amino acid derivative as an optically active form.
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https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/67579/1/manuscript.pdf

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