学術雑誌論文 Type XVII collagen coordinates proliferation in the interfollicular epidermis

Watanabe, Mika  ,  Natsuga, Ken  ,  Nishie, Wataru  ,  Kobayashi, Yasuaki  ,  Donati, Giacomo  ,  Suzuki, Shotaro  ,  Fujimura, Yu  ,  Tsukiyama, Tadasuke  ,  Ujiie, Hideyuki  ,  Shinkuma, Satoru  ,  Nakamura, Hideki  ,  Murakami, Masamoto  ,  Ozaki, Michitaka  ,  Nagayama, Masaharu  ,  Watt, Fiona M  ,  Shimizu, Hiroshi

6p.e26635 , 2017-07-11 , eLife Sciences Publications
ISSN:2050-084X
内容記述
Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. The replenishment of COL17 in the neonatal epidermis of COL17-null mice reverses the proliferative IFE phenotype and the altered Wnt signaling. Physical aging abolishes membranous COL17 in IFE basal cells because of inactive atypical protein kinase C signaling and also induces epidermal hyperproliferation. The overexpression of human COL17 in aged mouse epidermis suppresses IFE hypertrophy. These findings demonstrate that COL17 governs IFE proliferation of neonatal and aged skin in distinct ways. Our study indicates that COL17 could be an important target of anti-aging strategies in the skin.
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https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/67060/1/elife-26635-v1.pdf

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