Departmental Bulletin Paper Retrospective study of clinical and laboratory findings of autosomal recessive cholesterol deficiency in Holstein calves in Japan

Inokuma, Hisashi  ,  Horiuchi, Noriyuki  ,  Watanabe, Ken-ichi  ,  Kobayashi, Yoshiyasu

65 ( 2 )  , pp.107 - 112 , 2017-05 , Faculty of Veterinary Medicine, Hokkaido University
This retrospective study was conducted to clarify the clinical findings of an autosomal recessive cholesterol deficiency disorder in Holstein calves. Thirty-three calves with poor growth by uncertain causes from 2007 to 2016 comprised the study population of calves that were homozygous (n = 12) and non-homozygous (n = 21) for the disease. No significant group-dependent differences were found in the proportion with diarrhea or fever. Fewer calves with ataxia and anorexia were found in homozygotes. All affected calves showed muscular atrophy. Median RBC, Hb, and Ht values in affected calves were significantly lower. Median total cholesterol (TC) in homozygotes was extremely low, at 6.5 mg/dl (range, 5.0-15.0). TC readings under 10 mg/dl were thought to be suggestive of the disease.

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