Journal Article Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus : A single institution experience

Homma, Akihiro  ,  Nakamaru, Yuji  ,  Sakashita, Tomohiro  ,  Onimaru, Rikiya  ,  Terasaka, Shunsuke  ,  Tsuchiya, Kazuhiko  ,  Yoshida, Daisuke  ,  Yasuda, Koichi  ,  Hatakeyama, Hiromitsu  ,  Furusawa, Jun  ,  Mizumachi, Takatsugu  ,  Kano, Satoshi  ,  Shirato, Hiroki  ,  Fukuda, Satoshi

42 ( 5 )  , pp.377 - 381 , 2015-10 , Elsevier
Objective: Here we report our experience of patients with squamous cell carcinoma (SCC) of the nasal cavity and ethmoid sinus (NC&ES) together with an analysis of treatment outcomes. Methods: A retrospective analysis was performed using data from 25 consecutive patients treated between 2000 and 2012. Four patients were diagnosed with T1, 3 with T2, 4 with T3, 7 with T4a, and 7 with T4b disease. No patient had lymph node metastasis. Results: Twelve patients were treated with surgery with/without radiotherapy and with/without chemotherapy. Of these, 4 underwent endoscopic surgery without an open approach and 3 required an anterior skull base approach. Thirteen were treated with radiotherapy; 1 with radiotherapy alone, and 4 and 8 with intravenous and intra-arterial chemotherapy, respectively. The 5-yr overall survival for T1-3, T4a, and T4b disease was 53.9%, 71.4%, and 29.0%, respectively. The 5-yr disease-specific survival for T1-3, T4a, and T4b disease was 74.1%, 71.4%, and 29.0%, respectively. Conclusion: Our treatment policy for patients with SCC of NC&ES, which basically follows the NCCN guideline, was considered to be appropriate. However, several points in terms of surgery and nonsurgical approach remain to be solved through further research.

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