Journal Article Comparison of acute toxicities associated with cetuximab-based bioradiotherapy and platinum-based chemoradiotherapy for head and neck squamous cell carcinomas : A single-institution retrospective study in Japan

Sakashita, Tomohiro  ,  Homma, Akihiro  ,  Hatakeyama, Hiromitsu  ,  Furusawa, Jun  ,  Kano, Satoshi  ,  Mizumachi, Takatsugu  ,  Iizuka, Satoshi  ,  Onimaru, Rikiya  ,  Tsuchiya, Kazuhiko  ,  Yasuda, Koichi  ,  Shirato, Hiroki  ,  Fukuda, Satoshi

135 ( 8 )  , pp.853 - 858 , 2015-08 , Taylor & Francis
ISSN:0001-64891651-2251
NCID:AA0050923X
Description
Conclusion: Grade ≥ 3 mucositis/stomatitis and inability to feed orally were problematic for patients undergoing cetuximab-based bioradiotherapy (BRT) as well as platinum-based chemoradiotherapy (CRT). Severe mucositis/stomatitis and radiation dermatitis should be addressed carefully in patients undergoing cetuximab-based BRT as well. Objectives: The efficacy of cetuximab-based BRT in locally advanced head and neck squamous cell carcinomas has been established. However, the safety of cetuximab-based BRT in comparison with platinum-based CRT is currently under investigation. Method: This study retrospectively analyzed 14 patients undergoing cetuximab-based BRT and 29 patients undergoing platinum-based CRT to compare the incidence of acute toxicities. In the BRT group, an initial cetuximab loading dose of 400 mg/m2 was delivered 1 week before the start of radiotherapy. Seven weekly infusions of 250 mg/m2 of cetuximab followed during the definitive radiotherapy. In the CRT group, cisplatin was administered at a dose of 40 mg/m2 weekly during the definitive radiotherapy. Results: The BRT group had a higher incidence of Grade ≥ 3 radiation dermatitis than did the CRT group (43% vs 3%, respectively, p < 0.01). The incidence rate of Grade ≥ 3 mucositis/stomatitis was 64.3% and 41.4% in the BRT and CRT group, respectively (p = 0.1484), while the incidence rate of the inability to feed orally was 38.5% and 55.2%, respectively (p = 0.2053).
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http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/62577/1/manuscript.pdf

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