||First total synthesis of (+)-epogymnolactam, a novel autophagy inducer
Okado, Yuji ,
Shigetomi, Kengo Mitsuhashi, Shinya ,
724 , 2015-12 , 日本抗生物質学術協議会(Japan Antibiotics Research Association)
A novel autophagy inducer, (+)-epogymnolactam (1), was first synthesized from cis-4-benzyloxy-2-butene-1-ol (2) in eight steps. A reliable preparation of optically pure epoxy alcohol (+)-3 from monobenzyl derivative (2) was established by a tandem strategy, Sharpless epoxidation/lipase kinetic resolution.