Journal Article Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis

Oouchi, Manabu  ,  Hasebe, Akira  ,  Hata, Hironobu  ,  Segawa, Taku  ,  Yamazaki, Yutaka  ,  Yoshida, Yasuhiro  ,  Kitagawa, Yoshimasa  ,  Shibata, Ken-ichiro

21 ( 5 )  , pp.645 - 651 , 2015-07 , Wiley-Blackwell
ObjectiveRoles of aging or immune responses mediated by Toll-like receptors and natural killer cell in the onset or progression of human candidiasis remain unclear. This study was designed to elucidate the roles using peripheral blood mononuclear cells from healthy donors and patients with oral candidiasis. Subjects and methodsSubjects tested were healthy volunteers and patients who visited Dental Clinical Division of Hokkaido University Hospital. The patients with oral candidiasis included 39 individuals (25-89years of age) with major complaints on pain in oral mucosa and/or dysgeusia. Healthy volunteers include students (25-35years of age) and teaching staffs (50-65years of age) of Hokkaido University Graduate School of Dental Medicine. ResultsFunctions of Toll-like receptors 2 and 4 were downregulated significantly and the natural killer activity was slightly, but not significantly downregulated in aged healthy volunteers compared with healthy young volunteers. Functions of Toll-like receptors 2 and 4 and the natural killer activity were significantly downregulated in patients with oral candidiasis compared with healthy volunteers. ConclusionDownregulation of functions of Toll-like receptors 2 and 4 as well as natural killer activity is suggested to be associated with the onset or progression of oral candidiasis in human.

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