||Copper-Catalyzed gamma-Selective and Stereospecific Allylic Cross-Coupling with Secondary Alkylboranes
Yasuda, Yuto ,
Nagao, Kazunori ,
Shido, Yoshinori ,
Mori, Seiji Ohmiya, Hirohisa ,
Chemistry - A European Journal
9670 , 2015-06-26 , Wiley-Blackwell
The scope of the copper-catalyzed coupling reactions between organoboron compounds and allylic phosphates is expanded significantly by employing triphenylphosphine as a ligand for copper, allowing the use of secondary alkylboron compounds. The reaction proceeds with complete gamma-E-selectivity and preferential 1,3-syn stereoselectivity. The reaction of gamma-silicon-substituted allylic phosphates affords enantioenriched alpha-stereogenic allylsilanes.