||Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis
Kubota, Koji ,
Hayama, Keiichi ,
Iwamoto, HiroakiIto, Hajime
Angewandte chemie international edition
8813 , 2015-06-20 , Wiley-Blackwell
The enantioselective borylative dearomatization of a heteroaromatic compound has been achieved using a copper(I) catalyst and a diboron reagent. This reaction involves the regio- and enantioselective addition of active borylcopper(I) species to indole-2-carboxylates, followed by the diastereoselective protonation of the resulting copper(I) enolate to give the corresponding chiral indolines, which bear consecutive stereogenic centers.