Departmental Bulletin Paper Influence of fipronil intoxication on thyroid gland ultra-structure and hepatic microsomal enzymes expression in male albino rats

Ehsan, H. A.  ,  Mervat, H. G.  ,  Eman, W. E.  ,  Magdy, F. A.

64 ( 2 )  , pp.S79 - S85 , 2016-04
The aim of the current study is to investigate the impact of fipronil (FPN) insecticide oral exposure on thyroid gland and its related hormones in male albino rats. FPN was administered at dose of (4.85 mg/kg b.wt) twice weekly for 90 days. FPN exposed rats showed non-significant decrease in serum TSH level, while serum T3 and T4 levels showed significant decrease, significant increase in mRNA expression of hepatic uridine 5/- diphosphoglucuronosyl transferases (Ugt1a1) and sulfotransferases (Sult1b1) enzymes, Thyroid gland showed follicular disorganizations with severe vacuolation of the lining epithelium and extremely reduced sizes and colloid content. Ultra-structure of follicles showed damaged cells with detached microvilli and pyknotic nucleus. Mitochondria were degenerated with loss of cristae. It is concluded that alterations in thyroid hormones by FPN not only due to distress on physiology of the gland but more specifically due to its injurious effect on thyroidal tissue.

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