Departmental Bulletin Paper Assessment of the toxic impacts of acute exposure to fipronil insecticide on Japanese quails

Mohammed, Amany Tharwat  ,  Imam, Tamer Said  ,  Farag, Mayada Ragab  ,  Ghoneim, Mervat Hassan

64 ( 2 )  , pp.S243 - S249 , 2016-04 , Graduate School of Veterinary Medicine, Hokkaido University
The acute toxicity of fipronil on mature Japanese quails was investigated. Birds received a single oral dose of fipronil at doses of LD50 (11.3 mg ∕ kg), 1∕2 LD50 , 1∕5 LD50 and 1∕10 LD50. All the birds were slaughtered 96h post administration. Specimens from liver, muscle and abdominal fat were collected for applying single cell gel electrophoresis (SCGE) technique, histopathological examination and residual analysis of fipronil. Fipronil increased the percentage of DNA damage and the histopathological alterations in tissues of quails mostly at high doses. Fipronil were residues detected in all examined samples with variable concentrations even in the tissues of control group although there was no any clinical signs or symptoms.

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